Scanlan Lab (2019)

At the OHSU Department of Chemical Physiology and Biochemistry, I used a mouse model to study the pathology of a deadly human genetic disease called X-linked adrenoleukodystrophy (X-ALD) that causes demyelination and axonopathy in the central nervous system (CNS). I investigated two pharmacological strategies that enhance the effects of Sobetirome, a drug that reduces the abundance of neurotoxic very long chain fatty acids (VLCFAs) in X-ALD patients.